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Deprescribing · PPIs · Omeprazole · Reflux Medication

You were started on a PPI for reflux. That was years ago.

PPIs are among the most widely prescribed medications in the UK. Most were initiated for short-term use. Many patients have been on them for years without review. Stopping abruptly causes rebound acid hypersecretion, which is why a structured step-down is essential.

Full page coming soon
What this page will cover

The clinical case for a proper step-down plan.

Rebound acid hypersecretion

Why stopping PPIs abruptly makes symptoms worse than before you started, and how a gradual step-down prevents it.

Was the indication still valid?

GORD, H. pylori, NSAID co-prescription, Barrett's oesophagus: the indications that warrant long-term use versus those that don't.

Dietary trigger identification

The lifestyle changes that reduce gastric acid production and how to structure the environment for step-down success.

H2 blockers as a bridge

Using H2 antagonists as a step-down bridge between PPI and no medication.

Long-term PPI risks

Magnesium deficiency, vitamin B12 absorption, bone density, and kidney function: the evidence for long-term risks of continuing versus stopping.

Prokinetics and alternatives

Non-pharmacological and alternative approaches to reflux management during and after step-down.

In the meantime, if you have questions before this page is complete, contact the practice directly, or book a consultation online. Every enquiry is reviewed personally by Dr Dan Reardon.